rs4693075

A SNP in the COQ2 gene on chromosome 4. Its most notable genotype is G;G: 2x odds of myopathy if taking statins

Gene
COQ2
Location
Chr 483,271,015 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.058% of people
  2. G;GMost notableBad2x odds of myopathy if taking statinsWorth knowing · 2.110% of people

On SNPedia: (C;C), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 58% G;G 10%
  • European ancestry (Utah)C;C 45% G;G 12%
  • Han Chinese (Beijing)C;C 76% G;G 2%
  • Japanese (Tokyo)C;C 77% G;G 0%
  • Yoruba (Nigeria)C;C 33% G;G 25%

Conditions, medicines and genes

Other COQ2 SNPs

All COQ2 SNPs

Notes

From SNPedia

Notes

Non-coding polymorphism in intron 4 of the COQ2 gene; referred to as 'SNP2' in rs4693075(G;G) 2.3x odds of myopathy when taking statins Statin Response Warning: ambiguous flip confusion possible

G;G

see discussion on main rs-page

Source and license

Adapted from rs4693075 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.