rs6535454

A SNP in the COQ2 gene on chromosome 4. Its most notable genotype is A;A: 2x odds of myopathy if taking statins

Gene
COQ2
Location
Chr 483,269,878 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x odds of myopathy if taking statinsWorth knowing · 2.13% of people
  2. G;GGoodcommon/normalTypical · 0.079% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 3% G;G 79%
  • European ancestry (Utah)A;A 5% G;G 62%
  • Han Chinese (Beijing)A;A 0% G;G 85%
  • Japanese (Tokyo)A;A 0% G;G 90%
  • Yoruba (Nigeria)A;A 6% G;G 78%

Conditions, medicines and genes

Other COQ2 SNPs

All COQ2 SNPs

Notes

From SNPedia

Notes

Synonymous polymorphism in exon 5 of the COQ2 gene; referred to as 'SNP1' in rs6535454(A;A) 2.4x odds of myopathy when taking statins; note just on edge of being statistically significant at p<0.05. Statin Response

A;A

see discussion on main rs-page

Source and license

Adapted from rs6535454 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.