rs4894
A SNP in the ATF4 gene on chromosome 22. Its most notable genotype is A;A: normal
- Gene
- ATF4
- Location
- Chr 2239,521,510 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 25%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratednormal
- A;CNot rated1.78x increased risk for schizophrenia in males
- C;CNot rated1.78x increased risk for schizophrenia in males
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in one HapMap population.
- Yoruba (Nigeria)A;A 100% A;C 0% C;C 0%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
This SNP is on its own, as well as part of a specific haplotype, associated with an overall higher risk for schizophrenia in males based on a study of 352 Chinese patients (186 males). The reported odds ratio is 1.78 (CI: 1.19-2.67, p=0.004).
Source and license
Adapted from rs4894 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.