rs17001266

A SNP in the ATF4 gene on chromosome 22. Its most notable genotype is -;-: 1.58x increased risk for schizophrenia in males

Gene
ATF4
Location
Chr 2239,520,625 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
26%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;-Most notableBad1.58x increased risk for schizophrenia in malesWorth knowing · 2.0
  2. -;CBad1.58x increased risk for schizophrenia in malesWorth knowing · 2.0
  3. C;CGoodnormalTypical · 0.0

On SNPedia: (-;-), (-;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ATF4 SNPs

All ATF4 SNPs

Notes

From SNPedia

Notes

This SNP is on its own, as well as part of a specific haplotype, associated with an overall higher risk for schizophrenia in males based on a study of 352 Chinese patients (186 males). The reported odds ratio (for males only) is 1.58 (CI: 1.07-2.33, p=0.021).

Source and license

Adapted from rs17001266 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.