rs493258
A SNP in the LOC101928635 gene on chromosome 15. Its most notable genotype is C;T: 1.15x risk of Age Related Macular Degeneration
- Gene
- LOC101928635
- Location
- Chr 1558,395,681 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 46%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodNo summary available.
- C;TMost notableBad1.15x risk of Age Related Macular Degeneration
- C;CBad1.15x risk of Age Related Macular Degeneration
SNPedia records rs493258 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 35% C;T 47% C;C 18%
- European ancestry (Utah)T;T 26% C;T 50% C;C 24%
- Han Chinese (Beijing)T;T 50% C;T 39% C;C 11%
- Japanese (Tokyo)T;T 61% C;T 34% C;C 5%
- Yoruba (Nigeria)T;T 25% C;T 58% C;C 18%
- African ancestry (Southwest US)T;T 26% C;T 47% C;C 26%
- Chinese (Denver)T;T 49% C;T 43% C;C 8%
- Gujarati IndianT;T 52% C;T 35% C;C 14%
- Luhya (Kenya)T;T 28% C;T 46% C;C 26%
- Mexican ancestry (Los Angeles)T;T 12% C;T 57% C;C 31%
- Maasai (Kenya)T;T 39% C;T 50% C;C 10%
- TuscanT;T 16% C;T 55% C;C 29%
Related
Other LOC101928635 SNPs
- rs10468017C;Tassociated with higher HDL cholesterolWorth knowing
- rs1800588C;Thigher HDL-C levelsMinor
- rs539901T;Tcommon genotypeTypical
- rs2414539A;Acommon in complete genomicsTypical
- rs4775041C;Clowest phosphatidylethanolamine valuesTypical
- rs16939881G;Gcommon genotypeTypical
- rs16940212G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study.
Source and license
Adapted from rs493258 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.