rs4968451

A SNP in the BRIP1 gene on chromosome 17. Its most notable genotype is C;C: 2.33x increased risk for meningioma

Gene
BRIP1
Location
Chr 1761,849,946 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk for meningiomaTypical · 0.064% of people
  2. A;CBad1.61x increased risk for meningiomaWorth knowing · 2.027% of people
  3. C;CMost notableBad2.33x increased risk for meningiomaWorth knowing · 2.19% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 64% A;C 27% C;C 9%
  • European ancestry (Utah)A;A 73% A;C 27% C;C <1%
  • Han Chinese (Beijing)A;A 16% A;C 52% C;C 32%
  • Japanese (Tokyo)A;A 27% A;C 47% C;C 27%
  • Yoruba (Nigeria)A;A 89% A;C 10% C;C <1%
  • African ancestry (Southwest US)A;A 86% A;C 14% C;C 0%
  • Chinese (Denver)A;A 20% A;C 47% C;C 33%
  • Gujarati IndianA;A 80% A;C 20% C;C 0%
  • Luhya (Kenya)A;A 81% A;C 19% C;C 0%
  • Mexican ancestry (Los Angeles)A;A 69% A;C 28% C;C 3%
  • Maasai (Kenya)A;A 85% A;C 15% C;C 0%
  • TuscanA;A 80% A;C 19% C;C 1%

Conditions, medicines and genes

Other BRIP1 SNPs

All BRIP1 SNPs

Notes

From SNPedia

Notes

rs4968451, which is in a breast cancer susceptibility gene, was associated with increased risk of meningioma, a common form of brain tumor, in a combination of five studies totaling 631 European case patients as well 637 European control subjects. "Meningioma risks associated with hetero- and homozygosity for the minor allele of were 1.61 (95% CI = 1.26 to 2.06) and 2.33 (95% CI = 1.25 to 4.34), respectively, and were thus compatible with a multiplicative model of action." The risk allele and minor allele is rs4968451(C). Around 30% of Europeans carry one of risk genotypes, i.e. rs4968451(A;C) or (C;C); and perhaps 16% of meningiomas might be associated with this SNP.

Source and license

Adapted from rs4968451 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.