rs4986764
A SNP in the BRIP1 gene on chromosome 17. Its most notable genotype is A;A: common in clinvar
- Gene
- BRIP1
- Location
- Chr 1761,685,986 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 33%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs4986764 on the minus strand: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 11%
- European ancestry (Utah)A;A 14%
- Han Chinese (Beijing)A;A 7%
- Japanese (Tokyo)A;A 4%
- Yoruba (Nigeria)A;A 10%
- African ancestry (Southwest US)A;A 9%
- Chinese (Denver)A;A 7%
- Gujarati IndianA;A 33%
- Luhya (Kenya)A;A 7%
- Mexican ancestry (Los Angeles)A;A 5%
- Maasai (Kenya)A;A 16%
- TuscanA;A 13%
Related
Other BRIP1 SNPs
- rs137852986A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs149364097C;GOvarian cancer susceptibilityVery important
- rs368796923A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs574552037C;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs575595017A;GIncreased cancer risk; ovarian cancer & relatedVery important
- rs587778134-;TTOvarian cancer susceptibilityVery important
- rs587780226A;GOvarian cancer susceptibilityVery important
- rs587780228A;CIncreased cancer risk; ovarian cancer & relatedVery important
Notes
From SNPedia
Notes
Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. A recurrent truncating germline mutation in the BRIP1/FANCJ gene and susceptibility to prostate cancer. Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan. Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
Source and license
Adapted from rs4986764 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.