rs5029939

A SNP in the TNFAIP3 gene on chromosome 6. Its most notable genotype is C;C: common in complete genomics

Gene
TNFAIP3
Location
Chr 6137,874,586 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
12%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in complete genomicsTypical · 0.073% of people
  2. C;GBad1.67x increased risk of Sjogren's syndromeTypical · 0.022% of people
  3. G;GBad1.67x increased risk of Sjogren's syndromeTypical · 0.05% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 73% C;G 22% G;G 5%
  • European ancestry (Utah)C;C 95% C;G 5% G;G 0%
  • Han Chinese (Beijing)C;C 88% C;G 12% G;G 0%
  • Japanese (Tokyo)C;C 81% C;G 16% G;G 3%
  • Yoruba (Nigeria)C;C 31% C;G 48% G;G 21%
  • African ancestry (Southwest US)C;C 58% C;G 30% G;G 12%
  • Chinese (Denver)C;C 87% C;G 12% G;G <1%
  • Gujarati IndianC;C 93% C;G 7% G;G 0%
  • Luhya (Kenya)C;C 36% C;G 58% G;G 6%
  • Mexican ancestry (Los Angeles)C;C 97% C;G 3% G;G 0%
  • Maasai (Kenya)C;C 42% C;G 46% G;G 12%
  • TuscanC;C 92% C;G 8% G;G 0%

Other TNFAIP3 SNPs

All TNFAIP3 SNPs

Notes

From SNPedia

Notes

An association was found between Systemic lupus erythematosus (SLE) and rs5029939 (meta-analysis p = 2.89 x 10(-12), odds ratio 2.29).

Source and license

Adapted from rs5029939 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.