rs515726129

A SNP. Its most notable genotype is C;T: Possibly increased breast cancer risk, but see discussion

Gene
None listed
Highest magnitude
2.2Worth knowing
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableBadPossibly increased breast cancer risk, but see discussionWorth knowing · 2.2
  2. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.83A>G (p.Tyr28Cys) This missense variant in the PALB2 gene is reported based on a functional assay published in 2019 to significantly reduce DNA repair efficiency, and thereby to *potentially* significantly increase breast cancer risk. However, the extent of increased risk is unknown.

C;T

see discussion and links via main rs-page

Source and license

Adapted from rs515726129 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.