rs527236160
A SNP in the APOE gene on chromosome 19. Its most notable genotype is G;G: common in clinvar
- Gene
- APOE
- Location
- Chr 1944,908,587 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other APOE SNPs
- rs121918393A;ATwo copies of ApoE3 Christchurch variant (apparently)Very important
- rs121918394A;GHyperlipoproteinemia, type IIIVery important
- rs267606664A;GRare ApoE1 allele; clinical significance unclearVery important
- i5000217C;Tfamilial hyperlipoproteinemia, type IIIImportant
- rs387906567C;TFamilial type 3 hyperlipoproteinemiaImportant
- rs199768005A;TMarked reduced risk of Alzheimer's DiseaseWorth knowing
- rs449647T;Tlower levels of ApoEWorth knowing
- rs429358C;Cone of 2 snps relevant to classifying APOE genotypeMinor
Notes
From SNPedia
Show notes, about 120 words
Also known as c.291del or p.E97fs, this rare SNP in the APOE gene was found by whole-exome sequencing of the DNA of a patient with severe dysbetalipoproteinemia., The patient was homozygous for the minor/rare allele, rs527236160(-;-), yet despite the complete absence of apoE, he had "normal vision, exhibited normal cognitive, neurological, and retinal function, had normal findings on brain magnetic resonance imaging, and had normal cerebrospinal fluid levels of β-amyloid and tau proteins". He did have extremely high cholesterol levels (760 mg/dL) and mild atherosclerosis but otherwise no significant symptoms of cardiovascular disease. Overall, it appears as if apoE is not essential in the brain or eye.
Source and license
Adapted from rs527236160 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.