rs532464664

A SNP in the CHADL gene on chromosome 22. Its most notable genotype is CGCGCGCC;CGCGCGCC: Possible propensity to hip osteoarthritis

Gene
CHADL
Location
Chr 2241,238,083 (GRCh38)
Highest magnitude
3.9Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;-Goodcommon/normalTypical · 0.0
  2. CGCGCGCC;CGCGCGCCMost notableBadPossible propensity to hip osteoarthritisImportant · 3.9

On SNPedia: (-;-), (CGCGCGCC;CGCGCGCC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka p.Val330Glyfs*106, in the CHADL gene Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis: A study of 4,500+ Icelandic patients indicates that rs532464664 is associated with osteoarthritis through a recessive mode of inheritance (homozygote frequency = 0.15%, p = 4.5 × 10e−18, OR 7.71); on average, homozygous for rs532464664 had their hip replacement operation 4.9 years earlier than others (p = 0.0026),

CGCGCGCC;CGCGCGCC

see rs532464664

Source and license

Adapted from rs532464664 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.