rs56038477

A SNP. Its most notable genotype is T;T: Likely toxicity if treated with certain fluoropyrimidine-based chemotherapeutics

Gene
None listed
Highest magnitude
3.5Important
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;TBadCarrier of a decreased function DPYD gene alleleWorth knowing · 2.0
  3. T;TMost notableBadLikely toxicity if treated with certain fluoropyrimidine-based chemotherapeuticsImportant · 3.5

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.1236G>A (p.Glu412= or 412E); decreased function DPYD gene allele PharmGKB notes that cancer patients carrying a rs56038477(T) allele treated with fluoropyrimidine-based chemotherapy may have an increased risk for drug toxicities as compared to patients with the (C;C) genotype.

C;T

see main rs-page for details

T;T

see main rs-page for details

Source and license

Adapted from rs56038477 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.