rs570621429

A SNP in the GRK1 gene on chromosome 13. Its most notable genotype is A;A: Oguchi disease-2

Gene
GRK1
Location
Chr 13113,731,321 (GRCh38)
Highest magnitude
4.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadOguchi disease-2Very important · 4.0
  2. A;CBadCarrier of a pathogenic mutation for Oguchi disease-2Important · 3.0
  3. C;CGoodcommon/normalTypical · 0.0

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

GRK1 gene, c.1172C>A (p.Pro391His) One report in ClinVar links the minor allele to Oguchi disease, type 2, a recessively inherited condition.

A;A

see discussion

A;C

Unaffected unless carrying another pathogenic mutation in the GRK1 gene

Source and license

Adapted from rs570621429 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.