rs573225

A SNP in the G6PC2 gene on chromosome 2. Its most notable genotype is G;G: normal

Gene
G6PC2
Location
Chr 2168,901,031 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.03% of people
  2. A;GNot ratedhigher insulinogenic index in obese childrenTypical · 0.019% of people
  3. A;ANot ratedhigher insulinogenic index in obese childrenTypical · 0.079% of people

SNPedia records rs573225 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 3% A;G 19% A;A 79%
  • European ancestry (Utah)G;G 11% A;G 48% A;A 42%
  • Han Chinese (Beijing)G;G 0% A;G 10% A;A 91%
  • Japanese (Tokyo)G;G 2% A;G 17% A;A 81%
  • Yoruba (Nigeria)G;G 0% A;G 1% A;A 99%
  • African ancestry (Southwest US)G;G 0% A;G 12% A;A 88%
  • Chinese (Denver)G;G 0% A;G 7% A;A 93%
  • Gujarati IndianG;G 5% A;G 27% A;A 68%
  • Luhya (Kenya)G;G 0% A;G 2% A;A 98%
  • Mexican ancestry (Los Angeles)G;G 0% A;G 33% A;A 67%
  • Maasai (Kenya)G;G 0% A;G 14% A;A 87%
  • TuscanG;G 13% A;G 35% A;A 52%

Conditions, medicines and genes

Other G6PC2 SNPs

All G6PC2 SNPs

Notes

From SNPedia

Notes

rs573225 is a SNP in the glucose-6-phosphatase, catalytic, 2 G6PC2 gene. Based on a study of 734 young European children with obesity, the insulinogenic index (IGI) of insulin secretion was determined to be associated with rs573225 by linear regression analysis and was 30% greater in (T;T) or (C;T) genotypes than in (C;C) obese children (alleles oriented with respect to dbSNP). rs573225 was also associated with fasting glucose.

Source and license

Adapted from rs573225 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.