rs5743618

A SNP in the TLR1 gene on chromosome 4. Its most notable genotype is C;C: greater resistance to leprosy; but also consequence for Lyme patients

Gene
TLR1
Location
Chr 438,797,027 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodgreater resistance to leprosy; but also consequence for Lyme patientsWorth knowing · 2.0

SNPedia records rs5743618 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other TLR1 SNPs

All TLR1 SNPs

Notes

From SNPedia

Notes

C;C

This genotype leads to a lower susceptibility to acquire leprosy, but it is also reported to be associated more frequently with antibiotic-resistant arthritis in patients with Lyme disease.

Source and license

Adapted from rs5743618 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.