rs5743809

A SNP in the TLR6 gene on chromosome 4. Its most notable genotype is A;G: Carrier of a likely mutation for Kawasaki disease

Gene
TLR6
Location
Chr 438,828,893 (GRCh38)
Highest magnitude
3.0Important
Tested on
AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. A;GMost notableBadCarrier of a likely mutation for Kawasaki diseaseImportant · 3.02% of people
  2. A;AGoodcommon/normalTypical · 0.098% of people

SNPedia records rs5743809 on the minus strand: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;G 2% A;A 98%
  • European ancestry (Utah)A;G 0% A;A 100%
  • Han Chinese (Beijing)A;G 0% A;A 100%
  • Japanese (Tokyo)A;G 0% A;A 100%
  • Yoruba (Nigeria)A;G 6% A;A 94%

Conditions, medicines and genes

Other TLR6 SNPs

All TLR6 SNPs

Notes

From SNPedia

Notes

rs5743809, also known as p.Leu194Pro, represents an infrequent variant in the TLR6 gene. It is reported as likely to be causative, when inherited recessively (or as a compound heterozygote), for Kawasaki disease.

A;G

Unaffected in absence of another pathogenic mutation; see rs5743809

Source and license

Adapted from rs5743809 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.