rs58597806

A SNP in the UGT1A9 gene on chromosome 2. Its most notable genotype is T;T: likely reduced UGT1A9 glucuronidation

Gene
UGT1A9
Location
Chr 2233,672,700 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.0
  2. G;TNot ratedlikely reduced UGT1A9 glucuronidationMinor · 1.8
  3. T;TMost notableNot ratedlikely reduced UGT1A9 glucuronidationWorth knowing · 2.0

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs58597806 (Asp256Asn/D256N) is a SNP within UGT1A9 (UDP glucuronosyltransferase 1 family, polypeptide A9). reduced propofol glucuronidation - considerably lowered glucuronidation of mycophenolic acid, 1-naphthol, and naringenin. may be at risk adverse effects w/ propofol and other UGT1A9 substrate administration essentially non-functional with regard to SN-38 (7-ethyl-10-hydroxycamptothecin) glucuronidation, an active metabolite of irinotecan

Source and license

Adapted from rs58597806 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.