rs587776421
A SNP in the PALB2 gene on chromosome 16. Its most notable genotype is -;-: Fanconi anemia, complementation group N
- Gene
- PALB2
- Location
- Chr 1623,623,045 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadFanconi anemia, complementation group N
- -;AABadsignificantly increased risk of breast cancer
- AA;AAGoodcommon in clinvar
On SNPedia: (-;-), (-;AA), (AA;AA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PALB2 SNPs
- rs118203997T;TFanconi anemia, complementation group NVery important
- rs118203998C;CFanconi anemia, complementation group NVery important
- rs118203999A;AFanconi anemia, complementation group NVery important
- rs180177083A;AFanconi anemia, complementation group NVery important
- rs180177084-;-Fanconi anemia, complementation group NVery important
- rs180177085-;-Fanconi anemia, complementation group NVery important
- rs180177090-;-Fanconi anemia, complementation group NVery important
- rs180177091A;AFanconi anemia, complementation group NVery important
Notes
From SNPedia
Notes
-;-
see discussion at PALB2
-;AA
See the discussion and references at the SNPedia PALB2 gene page.
Source and license
Adapted from rs587776421 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.