rs587776716

A SNP in the CDKN2A gene on chromosome 9. Its most notable genotype is -;-: Significantly increased risk for melanoma and pancreatic cancer

Gene
CDKN2A
Location
Chr 921,971,115 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. -;-Most notableBadSignificantly increased risk for melanoma and pancreatic cancerVery important · 5.0
  2. -;CGGGTCGGGTGAGAGTGGCBadSignificantly increased risk for melanoma and pancreatic cancerVery important · 4.0
  3. CGGGTCGGGTGAGAGTGGC;CGGGTCGGGTGAGAGTGGCGoodcommon/normalTypical · 0.0

On SNPedia: (-;-), (-;CGGGTCGGGTGAGAGTGGC), (CGGGTCGGGTGAGAGTGGC;CGGGTCGGGTGAGAGTGGC). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other CDKN2A SNPs

All CDKN2A SNPs

Notes

From SNPedia

Show notes, about 120 words

rs587776716, known best as p16-Leiden but also as c.226_244del19, represents a rare mutation in the CDKN2A gene on chromosome 9. Noticed first and studied primarily in Dutch families with atypical multiple-mole melanoma, the deletion form of rs587776716 has now been linked to significantly increased risk for pancreatic cancer in addition to malignant melanoma. There do appear to be modifiers in the genomes of some individuals that can reduce the cancer risk of this allele. Increased screening of individuals with the p16-Leiden for both moles and pancreatic cancer is likely to be beneficial. A detailed description of this allele and studies about it can be found in OMIM 600160.0003.

-;-

see discussion at rs587776716

-;CGGGTCGGGTGAGAGTGGC

see discussion at rs587776716

Source and license

Adapted from rs587776716 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.