rs587782401
A SNP in the CHEK2 gene on chromosome 22. Its most notable genotype is A;T: Breast cancer associated mutation
- Gene
- CHEK2
- Location
- Chr 2228,734,401 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- A;TMost notableBadBreast cancer associated mutation
- A;AGoodcommon in clinvar
SNPedia records rs587782401 on the minus strand: (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CHEK2 SNPs
- rs121908702A;CBreast cancer associated mutationVery important
- rs137853007A;GBreast cancer associated mutationVery important
- rs587780183-;ABreast cancer associated mutationVery important
- rs587780184-;ABreast cancer associated mutationVery important
- rs587780186-;CBreast cancer associated mutationVery important
- rs587781269A;GBreast cancer associated mutationVery important
- rs587781592A;GBreast cancer associated mutationVery important
- rs587781699C;TBreast cancer associated mutationVery important
Notes
From SNPedia
Notes
Mentioned as a pathogenic/likely pathogenic mutation associated with cancer predisposition in
Source and license
Adapted from rs587782401 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.