rs5911
A SNP in the ITGA2B gene on chromosome 17. Its most notable genotype is C;C: BAK platelet-specific alloantigen
- Gene
- ITGA2B
- Location
- Chr 1744,375,697 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe
- Minor allele frequency
- 40%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in clinvar
- A;CNot ratedHeterozygous for BAK platelet-specific alloantigen
- C;CMost notableBadBAK platelet-specific alloantigen
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 56% A;C 33% C;C 11%
- European ancestry (Utah)A;A 47% A;C 45% C;C 8%
- Han Chinese (Beijing)A;A 33% A;C 40% C;C 27%
- Japanese (Tokyo)A;A 43% A;C 48% C;C 9%
- Yoruba (Nigeria)A;A 100% A;C 0% C;C 0%
Related
Other ITGA2B SNPs
- rs76811038G;GGlanzmann's thromboastheniaImportant
- rs80002943A;AGlanzmann's thromboastheniaImportant
- rs80277041G;GGlanzmann's thromboastheniaImportant
- rs137852906A;AGlanzmann's thromboastheniaImportant
- rs137852907T;TGlanzmann's thromboastheniaImportant
- rs137852908T;TGlanzmann's thromboastheniaImportant
- rs137852909T;TGlanzmann's thromboastheniaImportant
- rs137852910T;TGlanzmann's thromboastheniaImportant
Notes
From SNPedia
Notes
rs5911, also known as Ile874Ser or Ile843Ser, is a SNP in the ITGA2B gene on chromosome 17. In the context of the plus strand nomenclature used by dbSNP, rs5911(A) encodes the Ile, and rs5911(G) the Ser. The rs5911(C) allele gives rise to the platelet-specific alloantigen known as BAK. Of some historic interest in the field of platelet transfusion, the BAK alloantigen (rs5911(C;C) homozygotes) has more recently been reported in a small study of healthy Chinese males to be associated with decreased ex vivo antiplatelet activity of ticagrelor.
C;C
Possibly associated with reduced antiplatelet activity when taking ticagrelor.
Source and license
Adapted from rs5911 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.