rs62256378
A SNP in the SUCLG2 gene on chromosome 3. Its most notable genotype is A;A: slows rate of cognitive decline in Alzheimer's
- Gene
- SUCLG2
- Location
- Chr 367,406,609 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableGoodslows rate of cognitive decline in Alzheimer's
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
It was found that the minor allele (A) of rs62256378 in the SUCLG2 gene significantly reduced cognitive decline in AD patients (p=3.1x10-3,beta=0.32) {Beta represents attenuation in cognitive decline as measured in standard deviations of MMSE). This was only significant in epsilon 4 non carriers (p=0.021). Hum Mol Genet. 2014 Jul 15. pii: ddu372. SUCLG2 identified as both a determinator of CSF Aβ1-42-levels and an attenuator of cognitive decline in Alzheimer's disease
Source and license
Adapted from rs62256378 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.