rs6318(C;C)

1.4x increased risk for cardiac events in patients; apparently stress (cortisol) related

Magnitude
2.5Worth knowing
Repute
Bad
Frequency
12%Average of 4 populations
On SNPedia
rs6318(C;C)
Gene
HTR2C

Frequency

Share of people with C;C in each HapMap population.

  • Yoruba (Nigeria)33%
  • European ancestry (Utah)9%
  • Japanese (Tokyo)5%
  • Han Chinese (Beijing)2%

Other genotypes of rs6318

  1. C;GNot ratedFemale only, since on X ch; appears to mostly be = to common (G;G) genotypeTypical · 0.012% of people
  2. G;GGoodcommon in clinvarTypical · 0.076% of people

All about rs6318

Notes

From SNPedia

See rs6318. Male catheterization patients at ~1.2x increased risk for subsequent cardiac events, females at ~1.6x increased risk. Likely stronger emotional response to stress, and apparently (slightly?) higher risk for affective disorders (major depressive and bipolar disorders). Poorer lipid profiles have also been reported.

Source and license

Adapted from rs6318(C;C) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.