rs6435862

A SNP in the BARD1 gene on chromosome 2. Its most notable genotype is G;G: 2.8x higher risk of aggressive neuroblastoma

Gene
BARD1
Location
Chr 2214,807,822 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad2.8x higher risk of aggressive neuroblastomaWorth knowing · 2.06% of people
  2. G;TBad1.7x higher risk of aggressive neuroblastomaMinor · 1.533% of people
  3. T;TNot ratedNormal risk of aggressive neuroblastoma.Typical · 0.061% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 6% G;T 33% T;T 61%
  • European ancestry (Utah)G;G 8% G;T 45% T;T 47%
  • Han Chinese (Beijing)G;G 4% G;T 16% T;T 80%
  • Japanese (Tokyo)G;G 2% G;T 31% T;T 67%
  • Yoruba (Nigeria)G;G 8% G;T 42% T;T 50%
  • African ancestry (Southwest US)G;G 11% G;T 39% T;T 51%
  • Chinese (Denver)G;G 2% G;T 21% T;T 77%
  • Gujarati IndianG;G 11% G;T 38% T;T 52%
  • Luhya (Kenya)G;G 6% G;T 39% T;T 55%
  • Mexican ancestry (Los Angeles)G;G 5% G;T 26% T;T 69%
  • Maasai (Kenya)G;G 5% G;T 34% T;T 61%
  • TuscanG;G 5% G;T 32% T;T 63%

Conditions, medicines and genes

Other BARD1 SNPs

All BARD1 SNPs

Notes

From SNPedia

Notes

Each G allele has been associated with an allelic odds ratio of 1.68 (p = 8.65 x 10(-18)) for risk of aggressive neuroblastoma.

Source and license

Adapted from rs6435862 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.