rs6476
A SNP in the CYP21A2 gene on chromosome 6. Its most notable genotype is A;A: Congenital adrenal hyperplasia
- Gene
- CYP21A2
- Location
- Chr 632,039,816 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadCongenital adrenal hyperplasia
- A;TBadCarrier of allele for congenital adrenal hyperplasia
- T;TGoodcommon in clinvar
On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 0% A;T 1% T;T 99%
- European ancestry (Utah)A;A 0% A;T 0% T;T 100%
- Han Chinese (Beijing)A;A 0% A;T 0% T;T 100%
- Japanese (Tokyo)A;A 0% A;T 2% T;T 98%
- Yoruba (Nigeria)A;A 0% A;T 2% T;T 98%
Related
Conditions, medicines and genes
Other CYP21A2 SNPs
- rs6445T;TCongenital adrenal hyperplasiaVery important
- rs6471T;TCongenital adrenal hyperplasiaVery important
- rs6475A;ACongenital adrenal hyperplasiaVery important
- rs7755898T;TCongenital adrenal hyperplasiaVery important
- rs151344503A;ACongenital adrenal hyperplasiaVery important
- rs151344505A;ACongenital adrenal hyperplasiaVery important
- rs201552310A;ACongenital adrenal hyperplasiaVery important
- rs267606757C;CCongenital adrenal hyperplasiaVery important
Notes
From SNPedia
Notes
A;A
See discussion at Congenital adrenal hyperplasia
A;T
See discussion at Congenital adrenal hyperplasia
Source and license
Adapted from rs6476 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.