rs6596075

A SNP in the IBD5 gene on chromosome 5. Its most notable genotype is C;C: 2x risk of Crohn's disease

Gene
IBD5
Location
Chr 5132,406,536 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
25%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad2x risk of Crohn's diseaseTypical · 0.054% of people
  2. C;GBad1.5x riskTypical · 0.033% of people
  3. G;GNot ratednormalTypical · 0.013% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 54% C;G 33% G;G 13%
  • European ancestry (Utah)C;C 64% C;G 36% G;G 0%
  • Han Chinese (Beijing)C;C 77% C;G 21% G;G 2%
  • Japanese (Tokyo)C;C 91% C;G 9% G;G 0%
  • Yoruba (Nigeria)C;C 16% C;G 52% G;G 32%
  • African ancestry (Southwest US)C;C 23% C;G 58% G;G 19%
  • Chinese (Denver)C;C 81% C;G 19% G;G 0%
  • Gujarati IndianC;C 69% C;G 27% G;G 4%
  • Luhya (Kenya)C;C 15% C;G 45% G;G 41%
  • Mexican ancestry (Los Angeles)C;C 70% C;G 28% G;G 2%
  • Maasai (Kenya)C;C 19% C;G 44% G;G 37%
  • TuscanC;C 71% C;G 26% G;G 4%

Conditions, medicines and genes

Other IBD5 SNPs

All IBD5 SNPs

Notes

From SNPedia

Notes

rs6596075 has been reported in a large study to be associated with Crohn's disease. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.55 (CI 1.00-2.39), and for homozygotes, 2.06 (CI 1.35-3.14).

Source and license

Adapted from rs6596075 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.