rs6596189

A SNP in the C5orf66 gene on chromosome 5. Its most notable genotype is T;T.

Gene
C5orf66
Location
Chr 5135,032,479 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
16%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedNo summary available.Worth knowing · 2.07% of people

On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 7%
  • European ancestry (Utah)T;T 3%
  • Han Chinese (Beijing)T;T 0%
  • Japanese (Tokyo)T;T 0%
  • Yoruba (Nigeria)T;T 22%
  • African ancestry (Southwest US)T;T 9%
  • Chinese (Denver)T;T 0%
  • Gujarati IndianT;T 0%
  • Luhya (Kenya)T;T 20%
  • Mexican ancestry (Los Angeles)T;T 3%
  • Maasai (Kenya)T;T 16%
  • TuscanT;T 1%

Conditions, medicines and genes

Other C5orf66 SNPs

All C5orf66 SNPs

Notes

From SNPedia

Notes

Individuals homozygous or heterozygous for the rs11959298(A)-rs6596189(C) haplotype risk allele were 2.54 and 1.59 fold more likely to have autism, respectively, compared to rs11959298(G)-rs6596189(T) carriers. Note/caveat emptor: ~90% of the world's population carries what the authors from this for-profit genetic testing company call the "risk haplotype", yet the frequency of autism is less than 1% (perhaps 1 in 150).

Source and license

Adapted from rs6596189 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.