rs121909109

A SNP in the C5orf66 gene on chromosome 5. Its most notable genotype is C;T: Clubfoot (Talipes equinovarus); predicted

Gene
C5orf66
Location
Chr 5135,031,290 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;TMost notableBadClubfoot (Talipes equinovarus); predictedVery important · 5.0
  2. C;CGoodcommon in clinvarTypical · 0.0

SNPedia records rs121909109 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other C5orf66 SNPs

All C5orf66 SNPs

Notes

From SNPedia

Notes

aka c.388G>A (p.Glu130Lys) rs121909109 represents a variant in the PITX1 gene on chromosome 5; the rare rs121909109(A) allele is considered a dominant mutation leading to talipes equinovarus, based on an analysis of a 5-generation family segregating asymmetric right-sided predominant clubfoot.

C;T

see text and links via main rs-page

Source and license

Adapted from rs121909109 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.