rs664677

A SNP in the ATM gene on chromosome 11. Its most notable genotype is C;C: Lower lung cancer and increased breast cancer risk

Gene
ATM
Location
Chr 11108,272,455 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
39%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedLower lung cancer and increased breast cancer riskWorth knowing · 2.118% of people
  2. C;TNot ratedLower lung cancer and increased breast cancer riskWorth knowing · 2.142% of people

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 18% C;T 42%
  • European ancestry (Utah)C;C 20% C;T 53%
  • Han Chinese (Beijing)C;C 36% C;T 44%
  • Japanese (Tokyo)C;C 42% C;T 41%
  • Yoruba (Nigeria)C;C 3% C;T 35%
  • African ancestry (Southwest US)C;C 5% C;T 26%
  • Chinese (Denver)C;C 32% C;T 50%
  • Gujarati IndianC;C 10% C;T 39%
  • Luhya (Kenya)C;C 6% C;T 39%
  • Mexican ancestry (Los Angeles)C;C 21% C;T 43%
  • Maasai (Kenya)C;C 15% C;T 54%
  • TuscanC;C 12% C;T 33%

Conditions, medicines and genes

Other ATM SNPs

All ATM SNPs

Notes

From SNPedia

Show notes, about 170 words

Haplotype and linkage disequilibrium architecture for human cancer-associated genes. Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. ATM polymorphisms and risk of lung cancer among never smokers.

C;C

rs664677 polymorphism was associated with decreased lung cancer risk and increased breast cancer risk (for lung cancer: TC vs. TT: OR = 0.76, 95% CI 0.62-0.92, CC vs. TT: OR = 0.80, 95% CI 0.64-0.99 and for breast cancer: TC vs. TT: OR = 1.42, 95% CI 1.17-1.73, CC vs. TT: OR = 1.51, 95% CI 1.21-1.87). PMID 22203481

C;T

rs664677 polymorphism was associated with decreased lung cancer risk and increased breast cancer risk (for lung cancer: TC vs. TT: OR = 0.76, 95% CI 0.62-0.92, CC vs. TT: OR = 0.80, 95% CI 0.64-0.99 and for breast cancer: TC vs. TT: OR = 1.42, 95% CI 1.17-1.73, CC vs. TT: OR = 1.51, 95% CI 1.21-1.87). PMID 22203481

References

Source and license

Adapted from rs664677 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.