rs67608943

A SNP in the PCSK9 gene on chromosome 1. Its most notable genotype is C;G: 40% reduction in LDL-cholesterol

Gene
PCSK9
Location
Chr 155,046,549 (GRCh38)
Highest magnitude
3.0Important
Tested on
23andMe
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in complete genomicsTypical · 0.0
  2. C;GMost notableGood40% reduction in LDL-cholesterolImportant · 3.0
  3. G;GGoodStrong reduction in LDL-CImportant · 3.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other PCSK9 SNPs

All PCSK9 SNPs

Notes

From SNPedia

Notes

rs67608943, also known as Y142X, is a SNP in the PCSK9 gene. It has been reported in several studies (including ) to be both rare (2% frequency in Africans, 0.1% in Europeans) and as a dominant nonsense mutation a cause of plasma LDL-C levels being up to 40% lower than average. This lowered LDL-C level is thought to be directly associated with very significantly lowered risk for coronary events.

C;G

Lower plasma LDL-C, with predicted reduced risk for coronary events.

G;G

Likely to be very strong reduction in LDL-C and thereby coronary event risk.

Source and license

Adapted from rs67608943 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.