rs72646508
A SNP in the PCSK9 gene on chromosome 1. Its most notable genotype is C;T: Lowered LDL-C and reduced risk for coronary events
- Gene
- PCSK9
- Location
- Chr 155,052,749 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon
- C;TMost notableGoodLowered LDL-C and reduced risk for coronary events
- T;TGoodLower LDL-C and lowered risk for coronary events
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other PCSK9 SNPs
- rs28942112C;TFamilial HypercholesterolemiaVery important
- rs137852912C;GFamilial HypercholesterolemiaVery important
- rs793888521A;GFamilial HypercholesterolemiaVery important
- i5000370C;Tfamilial hypercholesterolemiaVery important
- rs11591147T;T2-3 fold lower risk of heart diseaseVery important
- rs28942111A;TFamilial hypercholesterolemiaVery important
- rs28362286A;ALowered LDL-C and lower risk for coronary eventsImportant
- rs67608943C;G40% reduction in LDL-cholesterolImportant
Notes
From SNPedia
Notes
rs72646508, also known as L253F, is a SNP in the PCSK9 gene. It has been reported in several studies (including and ) to be associated with reductions in total cholesterol as well as LDL-C, and most importantly, with significantly lowered risk for coronary events.
Source and license
Adapted from rs72646508 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.