rs6837293

A SNP in the PRKG2 gene on chromosome 4. Its most notable genotype is T;T: If Taiwanese, you might be 2.72 times more likely to develop gout

Gene
PRKG2
Location
Chr 481,141,777 (GRCh38)
Highest magnitude
2.7Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNo summary available.Typical · 0.025% of people
  2. T;TMost notableBadIf Taiwanese, you might be 2.72 times more likely to develop goutWorth knowing · 2.741% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 25% T;T 41%
  • European ancestry (Utah)C;C 71% T;T 2%
  • Han Chinese (Beijing)C;C 17% T;T 27%
  • Japanese (Tokyo)C;C 25% T;T 30%
  • Yoruba (Nigeria)C;C 0% T;T 97%
  • African ancestry (Southwest US)C;C 5% T;T 70%
  • Chinese (Denver)C;C 14% T;T 36%
  • Gujarati IndianC;C 43% T;T 13%
  • Luhya (Kenya)C;C 0% T;T 94%
  • Mexican ancestry (Los Angeles)C;C 39% T;T 11%
  • Maasai (Kenya)C;C 3% T;T 71%
  • TuscanC;C 55% T;T 4%

Conditions, medicines and genes

Other PRKG2 SNPs

All PRKG2 SNPs

Notes

From SNPedia

Notes

Two SNPs in the cGMP-dependent protein kinase II (cGK II) PRKG2 gene, rs7688672 and rs6837293, were found to be associated in 148 matched Taiwanese case:control subjects with gout disease using a recessive model after adjustment of hyperuricemia (odds ratio 2.72, CI: 1.13-6.54). Note that this was a relatively small study and since the original 2009 publication cited there has not been a publication confirming or replicating the finding.

T;T

see discussion at rs6837293

Source and license

Adapted from rs6837293 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.