rs7688672

A SNP in the PRKG2 gene on chromosome 4. Its most notable genotype is A;A: If Taiwanese, you might be ~3x more likely to develop gout

Gene
PRKG2
Location
Chr 481,148,295 (GRCh38)
Highest magnitude
2.8Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
46%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadIf Taiwanese, you might be ~3x more likely to develop goutWorth knowing · 2.841% of people
  2. G;GGoodNo summary available.Typical · 0.024% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 41% G;G 24%
  • European ancestry (Utah)A;A 2% G;G 68%
  • Han Chinese (Beijing)A;A 28% G;G 17%
  • Japanese (Tokyo)A;A 30% G;G 27%
  • Yoruba (Nigeria)A;A 95% G;G <1%
  • African ancestry (Southwest US)A;A 71% G;G 5%
  • Chinese (Denver)A;A 38% G;G 12%
  • Gujarati IndianA;A 13% G;G 41%
  • Luhya (Kenya)A;A 91% G;G 0%
  • Mexican ancestry (Los Angeles)A;A 12% G;G 38%
  • Maasai (Kenya)A;A 66% G;G 2%
  • TuscanA;A 4% G;G 55%

Conditions, medicines and genes

Other PRKG2 SNPs

All PRKG2 SNPs

Notes

From SNPedia

Notes

Two SNPs in the cGMP-dependent protein kinase II (cGK II) PRKG2 gene, rs7688672 and rs6837293, were found to be associated in 148 matched Taiwanese case:control subjects with gout disease using a recessive model after adjustment of hyperuricemia (odds ratio 2.72, CI: 1.13-6.54). Note that this was a relatively small study and since the original 2009 publication cited there has not been a publication confirming or replicating the finding. A 2015 paper of Han Chinese (listed below) found no significant association between rs7688672 on it's own and gout sensitivity, however, a haplotype including rs7688672 and a linked SNP had a weak association.

A;A

see discussion at rs7688672

Source and license

Adapted from rs7688672 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.