rs686

A SNP in the DRD1 gene on chromosome 5. Its most notable genotype is G;G.

Gene
DRD1
Location
Chr 5175,441,697 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Typical · 0.017% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 17%
  • European ancestry (Utah)G;G 12%
  • Han Chinese (Beijing)G;G 2%
  • Japanese (Tokyo)G;G 3%
  • Yoruba (Nigeria)G;G 38%
  • African ancestry (Southwest US)G;G 32%
  • Chinese (Denver)G;G 2%
  • Gujarati IndianG;G 17%
  • Luhya (Kenya)G;G 46%
  • Mexican ancestry (Los Angeles)G;G 7%
  • Maasai (Kenya)G;G 19%
  • TuscanG;G 15%

Conditions, medicines and genes

Other DRD1 SNPs

All DRD1 SNPs

Notes

From SNPedia

Show notes, about 180 words

Implicated as part of a haplotype of the dopamine D1 receptor DRD1 gene associated with autism spectrum disorders in families having only affected males. The haplotype is rs265981(C)-rs4532(A)-rs686(T) as published, though not necessarily as oriented in dbSNP. Significant association of DRD1 with nicotine dependence. A haplotype of the DRD1 gene is associated with alcohol dependence. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504. Heroin addiction in African Americans: a hypothesis-driven association study. Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response. An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia. Dopamine receptors D1 and D2 are related to observed maternal behavior.

Source and license

Adapted from rs686 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.