rs6897932

A SNP in the IL7R gene on chromosome 5. Its most notable genotype is T;T: 0.70x decreased risk for multiple sclerosis

Gene
IL7R
Location
Chr 535,874,473 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBad1.08x increased risk for multiple sclerosisWorth knowing · 2.072% of people
  2. C;TGood0.91x decreased risk for multiple sclerosisMinor · 1.825% of people
  3. T;TMost notableGood0.70x decreased risk for multiple sclerosisWorth knowing · 2.13% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 72% C;T 25% T;T 3%
  • European ancestry (Utah)C;C 59% C;T 33% T;T 8%
  • Han Chinese (Beijing)C;C 70% C;T 23% T;T 7%
  • Japanese (Tokyo)C;C 66% C;T 31% T;T 3%
  • Yoruba (Nigeria)C;C 91% C;T 10% T;T 0%
  • African ancestry (Southwest US)C;C 81% C;T 16% T;T 4%
  • Chinese (Denver)C;C 63% C;T 34% T;T 3%
  • Gujarati IndianC;C 72% C;T 27% T;T 1%
  • Luhya (Kenya)C;C 90% C;T 10% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 62% C;T 33% T;T 5%
  • Maasai (Kenya)C;C 80% C;T 19% T;T 1%
  • TuscanC;C 58% C;T 39% T;T 3%

Conditions, medicines and genes

Other IL7R SNPs

All IL7R SNPs

Notes

From SNPedia

Show notes, about 200 words

The (C) allele of rs6897932, located in the alternatively spliced exon 6 of IL7RA gene and encoding the amino acid threonine rather than isoleucine at amino acid position 244, is associated with a slight increase (18%) in risk of developing multiple sclerosis. PMID 17660817; Nature Genetics 39, 1083 - 1091 (2007) SG Gregory et al.] Note that the (C) allele is the most common at this position in all known populations and influences the ratios of the alternative isoforms (membrane bound and soluble) of the gene. Thus, we consider the (T) allele protective. blog post giving perspective on the significance of this snp a significant risk factor for multiple sclerosis in four independent (overall P = 2.9 x 10(-7)) influences the amount of soluble and membrane-bound isoforms of the protein by putatively disrupting an exonic splicing silencer. nejm C allele increasing the risk of multiple sclerosis (odds ratio, approximately 1.2) A replication case-control study involving 599 Spanish patients with multiple sclerosis yielded a per allele odds ratio of 1.32 per rs6897932(C), (CI: 1.1-1.6, p = 0.0031), and odds per (C;C) genotype vs (T;T) and (C;T) genotypes of 1.5 (CI: 1.18-1.87, p = 0.0007).

Source and license

Adapted from rs6897932 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.