rs699473

A SNP in the SOD3 gene on chromosome 4. Its most notable genotype is C;C: ~1.5x increased brain tumor risk

Gene
SOD3
Location
Chr 424,795,181 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad~1.5x increased brain tumor riskMinor · 1.541% of people
  2. C;TBad~1.5x increased brain tumor riskMinor · 1.540% of people
  3. T;TGoodNormal brain tumor riskMinor · 1.019% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 41% C;T 40% T;T 19%
  • European ancestry (Utah)C;C 10% C;T 49% T;T 41%
  • Han Chinese (Beijing)C;C 44% C;T 38% T;T 18%
  • Japanese (Tokyo)C;C 45% C;T 46% T;T 10%
  • Yoruba (Nigeria)C;C 57% C;T 34% T;T 9%
  • African ancestry (Southwest US)C;C 62% C;T 27% T;T 11%
  • Chinese (Denver)C;C 45% C;T 42% T;T 13%
  • Gujarati IndianC;C 23% C;T 48% T;T 30%
  • Luhya (Kenya)C;C 67% C;T 27% T;T 6%
  • Mexican ancestry (Los Angeles)C;C 28% C;T 39% T;T 33%
  • Maasai (Kenya)C;C 56% C;T 37% T;T 8%
  • TuscanC;C 20% C;T 52% T;T 28%

Conditions, medicines and genes

Other SOD3 SNPs

All SOD3 SNPs

Notes

From SNPedia

Notes

A study of non-Hispanic Caucasians with various types of brain tumors concluded that there was an increased risk of glioma (odds ratio 1.3, CI: 1.0-1.7) and meningioma (odds ratio 1.7, CI: 1.1-2.7) associated with the rs699473(C) allele.

Source and license

Adapted from rs699473 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.