rs8192288

A SNP in the SOD3 gene on chromosome 4. Its most notable genotype is G;G: normal

Gene
SOD3
Location
Chr 424,795,056 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
6%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratednormalTypical · 0.0
  2. G;TNot ratednormalTypical · 0.0
  3. T;TNot ratedpossibly reduced lung function, see detailsTypical · 0.0

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SOD3 SNPs

All SOD3 SNPs

Notes

From SNPedia

Notes

rs8192287 and the nearby rs8192288 are both SNPs in the superoxide dismutase 3 SOD3 gene. This gene encodes a protein that inhibits breakdown of lung matrix components such as collagen. A large study ultimately genotyping over 45,000 Danish adults concludes that the very rare individuals who carry only minor alleles at both rs8192287 and rs8192288 have reduced (by 7%) lung capacity compared to noncarriers. They are also at higher risk (2.5x or 3.7x, respectively) for being hospitalized in association with, or dying from, chronic obstructive pulmonary disease, also known as COPD.

Source and license

Adapted from rs8192288 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.