rs699947

A SNP in the VEGFA gene on chromosome 6. Its most notable genotype is A;A: 1.36x increased risk for thyroid cancer in men

Gene
VEGFA
Location
Chr 643,768,652 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated1.36x increased risk for thyroid cancer in menTypical · 0.012% of people
  2. A;CNot rated1.36x increased risk for thyroid cancer in menTypical · 0.038% of people
  3. C;CNot ratednormalTypical · 0.050% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 12% A;C 38% C;C 50%
  • European ancestry (Utah)A;A 21% A;C 55% C;C 25%
  • Han Chinese (Beijing)A;A 5% A;C 38% C;C 56%
  • Japanese (Tokyo)A;A 17% A;C 39% C;C 44%
  • Yoruba (Nigeria)A;A 2% A;C 24% C;C 74%
  • African ancestry (Southwest US)A;A 0% A;C 33% C;C 67%
  • Chinese (Denver)A;A 12% A;C 36% C;C 52%
  • Gujarati IndianA;A 14% A;C 43% C;C 44%
  • Luhya (Kenya)A;A 4% A;C 25% C;C 71%
  • Mexican ancestry (Los Angeles)A;A 12% A;C 55% C;C 33%
  • Maasai (Kenya)A;A 7% A;C 29% C;C 64%
  • TuscanA;A 35% A;C 43% C;C 23%

Conditions, medicines and genes

Other VEGFA SNPs

All VEGFA SNPs

Notes

From SNPedia

Notes

rs699947 (-2578C>A) is a SNP within close proximity of VEGFA (Vascular endothelial growth factor A). The A allele of rs699947 increased a risk for thyroid cancer (adjusted OR=1.36, 95% C.I=1.02~1.81, P=0.039) and regional lymph node metastasis only in men.

Source and license

Adapted from rs699947 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.