rs7089424

A SNP in the ARID5B gene on chromosome 10. Its most notable genotype is G;G: moderately (~4x) increased risk for acute lymphoblastic leukemia

Gene
ARID5B
Location
Chr 1061,992,400 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadmoderately (~4x) increased risk for acute lymphoblastic leukemiaWorth knowing · 2.511% of people
  2. G;TBadsomewhat (~2x) increased risk for acute lymphoblastic leukemiaMinor · 1.545% of people
  3. T;TGoodcommon/normalTypical · 0.044% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 11% G;T 45% T;T 44%
  • European ancestry (Utah)G;G 9% G;T 43% T;T 48%
  • Han Chinese (Beijing)G;G 10% G;T 46% T;T 45%
  • Japanese (Tokyo)G;G 12% G;T 46% T;T 43%
  • Yoruba (Nigeria)G;G 8% G;T 30% T;T 63%
  • African ancestry (Southwest US)G;G 4% G;T 49% T;T 47%
  • Chinese (Denver)G;G 12% G;T 48% T;T 40%
  • Gujarati IndianG;G 41% G;T 47% T;T 13%
  • Luhya (Kenya)G;G 2% G;T 39% T;T 59%
  • Mexican ancestry (Los Angeles)G;G 5% G;T 64% T;T 31%
  • Maasai (Kenya)G;G 2% G;T 39% T;T 59%
  • TuscanG;G 16% G;T 50% T;T 34%

Other ARID5B SNPs

All ARID5B SNPs

Notes

From SNPedia

Notes

Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence.

G;G

see references at rs7089424, including meta-analyses

G;T

see references at rs7089424, including meta-analyses

Source and license

Adapted from rs7089424 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.