rs10821936

A SNP in the ARID5B gene on chromosome 10. Its most notable genotype is C;C: Higher risk of childhood acute lymphoblastic leukemia

Gene
ARID5B
Location
Chr 1061,963,818 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadHigher risk of childhood acute lymphoblastic leukemiaWorth knowing · 2.511% of people
  2. C;TBadHigher risk of childhood acute lymphoblastic leukemiaWorth knowing · 2.142% of people
  3. T;TNot ratednormalTypical · 0.048% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 11% C;T 42% T;T 48%
  • European ancestry (Utah)C;C 10% C;T 43% T;T 48%
  • Han Chinese (Beijing)C;C 7% C;T 45% T;T 47%
  • Japanese (Tokyo)C;C 12% C;T 44% T;T 43%
  • Yoruba (Nigeria)C;C 8% C;T 24% T;T 68%
  • African ancestry (Southwest US)C;C 2% C;T 33% T;T 65%
  • Chinese (Denver)C;C 12% C;T 50% T;T 38%
  • Gujarati IndianC;C 42% C;T 45% T;T 14%
  • Luhya (Kenya)C;C 3% C;T 30% T;T 67%
  • Mexican ancestry (Los Angeles)C;C 5% C;T 62% T;T 33%
  • Maasai (Kenya)C;C 5% C;T 30% T;T 65%
  • TuscanC;C 15% C;T 51% T;T 34%

Other ARID5B SNPs

All ARID5B SNPs

Notes

From SNPedia

Show notes, about 140 words

C;C

Consistently, when we further classified children into age groups of those aged less than 5 years, those aged 5 to 10 years, and those aged greater than 10 years, there was a trend for decreasing allelic odds ratio (ie, relative risk of ALL conferred by each copy of the C allele at rs10821936) as age increased: 2.01 (95% CI = 1.85 to 2.19), 1.8 (95% CI = 1.6 to 2.02), and 1.48 (95% CI = 1.3 to 1.68), respectively. PMID 23512250

C;T

Consistently, when we further classified children into age groups of those aged less than 5 years, those aged 5 to 10 years, and those aged greater than 10 years, there was a trend for decreasing allelic odds ratio (ie, relative risk of ALL conferred by each copy of the C allele at rs10821936) as age increased: 2.01 (95% CI = 1.85 to 2.19), 1.8 (95% CI = 1.6 to 2.02), and 1.48 (95% CI = 1.3 to 1.68), respectively. PMID 23512250

References

Source and license

Adapted from rs10821936 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.