rs7151526
A SNP in the SERPINA1 gene on chromosome 14. Its most notable genotype is A;A: possible increased risk for ANCA associated vasculitis
- Gene
- SERPINA1
- Location
- Chr 1494,397,299 (GRCh38)
- Highest magnitude
- 1.1Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 5 HapMap populations.
- AverageA;A <1% C;C 92%
- European ancestry (Utah)A;A <1% C;C 88%
- African ancestry (Southwest US)A;A 0% C;C 98%
- Gujarati IndianA;A 0% C;C 90%
- Mexican ancestry (Los Angeles)A;A 0% C;C 91%
- TuscanA;A 0% C;C 92%
Related
Other SERPINA1 SNPs
- rs28929474T;TAlpha-1 Antitrypsin DeficiencyVery important
- rs121912713A;CBleeding disorder likelyVery important
- rs267606950-;-Alpha1-anti-trypsin deficient homozygote; emphysema possibleVery important
- rs28931568T;Thigh risk of emphysema due to Alpha 1-Antitrypsin DeficiencyVery important
- rs28931569G;Ghigh risk of emphysemaVery important
- rs61761869A;APossible Alpha-1 Antrypsin deficiency genotypeImportant
- rs11558261C;Tcarrier for Alpha-1 Antitrypsin DeficiencyImportant
- rs28929472A;ANo summary available.Important
Notes
From SNPedia
Notes
rs7151526 is an SNP in the 5'UTR of the SERPINA1 (alpha-1-antritrypsin/AAT) gene, with potential effects on AAT activity. A recent study showed a strong association of the rs7151526(A) allele with anca-associated vasculitides
A;A
Homozygous Variant of SNP upstream of SERPINA1 which may cause alpha-1-antitrypsin reduction / deficiency, also associated with granulomatosis with polyangiitis, an ANCA-associated vasculitis which can damage the kidneys and lungs. NC_000014.8:g.94863636C>A NC_000014.9:g.94397299C>A
References
Source and license
Adapted from rs7151526 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.