rs71785313

A SNP in the APOL1 gene on chromosome 22. Its most notable genotype is -;-: ~6x higher risk for end-stage renal disease

Gene: APOL1
Location: Chr 2236,266,000 (GRCh38)
Highest magnitude: 5.5Very important
Tested on: 23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

On SNPedia: (-;-), (-;TTATAA), (TTATAA;TTATAA). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other APOL1 SNPs

All APOL1 SNPs

Genosets

Gs329~6x higher risk for end-stage renal diseaseVery important

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 140 words

The derived allele of indel rs71785313 (p.NYK388K) defines the APOL1 G2 allele. This allele has been shown to associate with kidney disease while conferring protection against Trypanosoma brucei rhodesiense. SNP rs143830837, a term used in some older literature, is identical to rs71785313 and was merged into it by dbSNP. gs329 represents "double heterozygotes". Nearby variant rs12106505 is almost a complete proxy (r2>95%), so it can be used as an alternative for genotyping, especially in cases where the technology does not work well with indels.

-;-

see text and links via main rs-page; this is a genotype of high interest for African-Americans, especially those considering donating or receiving a kidney

-;TTATAA

see text and links via main rs-page; this is a genotype of high interest for African-Americans, especially those considering donating or receiving a kidney

Source and license

Adapted from rs71785313 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.