rs73885319

A SNP in the APOL1 gene on chromosome 22. Its most notable genotype is G;G: ~6x higher risk for end-stage renal disease

Gene
APOL1
Location
Chr 2236,265,860 (GRCh38)
Highest magnitude
5.5Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon in complete genomicsTypical · 0.0
  2. A;GBad~3x higher risk for end-stage renal diseaseVery important · 4.5
  3. G;GMost notableBad~6x higher risk for end-stage renal diseaseVery important · 5.5

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other APOL1 SNPs

All APOL1 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Show notes, about 160 words

The derived allele of coding SNP rs73885319 (p.S342G) defines, together with the derived allele of coding SNP rs60910145 (p.I384M), the APOL1 G1 allele. This allele has been shown to associate with kidney disease while conferring protection against Trypanosoma brucei rhodesiense. gs329 represents G1/G2 "double heterozygotes".

A;G

see text and links via main rs-page; this is a genotype of high interest for African-Americans, especially those considering donating or receiving a kidney; note that this genotype is usually co-inherited with rs60910145(G;T), so the total risk increase from seeing both in a Promethease report is the same (~3x) as seeing one

G;G

see text and links via main rs-page; this is a genotype of high interest for African-Americans, especially those considering donating or receiving a kidney; note that this genotype is usually co-inherited with rs60910145(G;G), so the total risk increase from seeing both in a Promethease report is the same (~6x) as seeing one.

Source and license

Adapted from rs73885319 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.