rs71799110

A SNP in the FBXO7 gene on chromosome 22. Its most notable genotype is G;G: Parkinson disease, type 15

Gene
FBXO7
Location
Chr 2232,493,269 (GRCh38)
Highest magnitude
7.0Very important
Tested on
23andMe, AncestryDNA
Minor allele frequency
<1%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon in clinvarTypical · 0.0
  2. C;GBadCarrier of a Parkinson disease mutationImportant · 3.0
  3. G;GMost notableBadParkinson disease, type 15Very important · 7.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Other FBXO7 SNPs

All FBXO7 SNPs

Notes

From SNPedia

Notes

aka c.1132C>G (p.Arg378Gly or R378G) Considered "definitely pathogenic" in the Movement Disorder Society Genetic mutation database (MDSGene) for autosomal recessive Parkinson disease (type 15) See also OMIM 605648.0001 Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays.

C;G

Unaffected in absence of a second mutation in the FBXO7 gene

G;G

See text and links via main rs-page

Source and license

Adapted from rs71799110 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.