rs727504382
A SNP in the MAP2K2 gene on chromosome 19. Its most notable genotype is C;T: Rasopathy; Cardio-facio-cutaneous syndrome
- Gene
- MAP2K2
- Location
- Chr 194,101,105 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadRasopathy; Cardio-facio-cutaneous syndrome
- C;CGoodcommon in clinvar
SNPedia records rs727504382 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MAP2K2 SNPs
- rs121434497A;CRasopathy; Cardio-facio-cutaneous syndromeVery important
- rs121434498A;CRasopathy; Cardio-facio-cutaneous syndromeVery important
- rs121434499A;GRasopathy; Cardio-facio-cutaneous syndromeVery important
- rs267607230G;TLikely miscall in DNA chip (microarray) data such as from Ancestry, 23andMe or others; otherwise, Rasopathy, Cardio-facio-cutaneous syndromeVery important
- rs727504370C;TRasopathy; Cardio-facio-cutaneous syndromeVery important
Notes
From SNPedia
Notes
aka c.619G>A (p.Glu207Lys)
C;T
See links via main rs-page
Source and license
Adapted from rs727504382 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.