rs730880130
A SNP in the LDLR gene on chromosome 19. Its most notable genotype is C;T: Familial Hypercholesterolemia
- Gene
- LDLR
- Location
- Chr 1911,113,644 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;TMost notableBadFamilial Hypercholesterolemia
- G;TBadFamilial Hypercholesterolemia
- T;TGoodcommon in clinvar
On SNPedia: (C;T), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other LDLR SNPs
- rs121908027-;-familial hypercholesterolemiaVery important
- rs5933C;GFamilial HypercholesterolemiaVery important
- rs2228671A;CFamilial HypercholesterolemiaVery important
- rs2569548C;TFamilial HypercholesterolemiaVery important
- rs11547917A;CFamilial HypercholesterolemiaVery important
- rs13306512A;CFamilial HypercholesterolemiaVery important
- rs13306515A;CFamilial HypercholesterolemiaVery important
- rs28941776A;GFamilial HypercholesterolemiaVery important
Notes
From SNPedia
Notes
aka c.1468T>C, p.Trp490Arg or W490R reported in ClinVar as pathogenic for familial hypercholesterolemia and therefore increased risk for coronary artery disease
Source and license
Adapted from rs730880130 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.