rs730880657
A SNP in the MYBPC3 gene on chromosome 11. Its most notable genotype is -;CTACAGCGTGG: Familial Hypertrophic Cardiomyopathy
- Gene
- MYBPC3
- Location
- Chr 1147,335,895 (GRCh38)
- Highest magnitude
- 6.2Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;CTACAGCGTGGMost notableBadFamilial Hypertrophic Cardiomyopathy
- CTACAGCGTGG;CTACAGCGTGGGoodcommon in clinvar
On SNPedia: (-;CTACAGCGTGG), (CTACAGCGTGG;CTACAGCGTGG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MYBPC3 SNPs
- rs397515963C;CLikely severe cardiomyopathyVery important
- rs200411226C;THypertrophic CardiomyopathyVery important
- rs375882485A;Gfamilial hypertrophic cardiomyopathy mutationVery important
- rs786204338C;GHypertrophic CardiomyopathyVery important
- rs1060501474G;THypertrophic CardiomyopathyVery important
- rs111683277C;TFamilial Hypertrophic CardiomyopathyVery important
- rs111729952C;TFamilial Hypertrophic CardiomyopathyVery important
- rs113358486A;CFamilial Hypertrophic CardiomyopathyVery important
Notes
From SNPedia
Notes
This is expected to be a truncating variant resulting in a abnormal or absent protein. Truncating variants of MYBPC3 are usually pathogenic for HCM. Submitters to ClinVar have reported one individual with Familial Hypertrophic Cardiomyopathy. ncbi.nlm.nih.gov
Source and license
Adapted from rs730880657 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.