rs75087725
A SNP in the C21orf2 gene on chromosome 21. Its most notable genotype is A;C: Slight (~1.67x) increase in risk for ALS
- Gene
- C21orf2
- Location
- Chr 2144,333,234 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadSlight (~1.67x) increase in risk for ALS
- C;CGoodcommon/normal
On SNPedia: (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Notes
From SNPedia
Notes
Originally reported in 2016 as a minor risk factor for ALS, and subsequently replicated in at least two other studies, including in which the odds ratio for rs75087725(A) was 1.67 (CI:1.46-1.91, p=2x10-e-14).
A;C
see citations via main rs-page
Source and license
Adapted from rs75087725 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.