rs7536563

A SNP in the FAM69A gene on chromosome 1. Its most notable genotype is A;A: >1.12x risk of multiple sclerosis

Gene
FAM69A
Location
Chr 192,883,489 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.12x risk of multiple sclerosisWorth knowing · 2.016% of people
  2. A;GBad1.12x risk of multiple sclerosisMinor · 1.538% of people
  3. G;GGoodcommonTypical · 0.046% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 16% A;G 38% G;G 46%
  • European ancestry (Utah)A;A 11% A;G 49% G;G 41%
  • Han Chinese (Beijing)A;A 0% A;G 9% G;G 91%
  • Japanese (Tokyo)A;A 0% A;G 7% G;G 93%
  • Yoruba (Nigeria)A;A 39% A;G 52% G;G 10%
  • African ancestry (Southwest US)A;A 19% A;G 65% G;G 16%
  • Chinese (Denver)A;A 0% A;G 15% G;G 85%
  • Gujarati IndianA;A 10% A;G 35% G;G 55%
  • Luhya (Kenya)A;A 43% A;G 44% G;G 14%
  • Mexican ancestry (Los Angeles)A;A 9% A;G 46% G;G 46%
  • Maasai (Kenya)A;A 36% A;G 53% G;G 12%
  • TuscanA;A 10% A;G 45% G;G 46%

Conditions, medicines and genes

Other FAM69A SNPs

All FAM69A SNPs

Notes

From SNPedia

Notes

rs7536563 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with this allele is 1.12 (CI 1.06-1.18).

Source and license

Adapted from rs7536563 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.