rs769455
A SNP in the APOE gene on chromosome 19. Its most notable genotype is C;C: common in clinvar
- Gene
- APOE
- Location
- Chr 1944,908,783 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 3 HapMap populations.
- AverageC;C 95%
- Yoruba (Nigeria)C;C 94%
- African ancestry (Southwest US)C;C 96%
- Luhya (Kenya)C;C 96%
Related
Other APOE SNPs
- rs121918393A;ATwo copies of ApoE3 Christchurch variant (apparently)Very important
- rs121918394A;GHyperlipoproteinemia, type IIIVery important
- rs267606664A;GRare ApoE1 allele; clinical significance unclearVery important
- i5000217C;Tfamilial hyperlipoproteinemia, type IIIImportant
- rs387906567C;TFamilial type 3 hyperlipoproteinemiaImportant
- rs199768005A;TMarked reduced risk of Alzheimer's DiseaseWorth knowing
- rs449647T;Tlower levels of ApoEWorth knowing
- rs429358C;Cone of 2 snps relevant to classifying APOE genotypeMinor
Notes
From SNPedia
Notes
The ancestral allele is C. Association of ApoE genetic variants with obstructive sleep apnea in children. Subarachnoid hemorrhage: tests of association with apolipoprotein E and elastin genes.
Source and license
Adapted from rs769455 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.